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ThyroPIX

New generation camera for thyroid gland and small organs imaging by nuclear medicine methods.

ABOUT PROJECT

This project is co-financed from the state budget by the Technology agency of the Czech Republic under the TREND Progamme.

 

The consortium was established upon the previous long-term cooperation of all the incorporated companies.
Advacam s.r.o. is the leader of the project, it experienced several successfully finished projects in the past not only in Czech Republic, but in international scale as well. ADVACAM is responsible for the part dedicated to the development of the detectors and advanced imaging methods.
ThyroPIX will bring an efficient instrument to meet the 2018/02 implemented EU ordinance 2013/59/EURATOM requirements on radiation therapy planning and verification which is problematical in nuclear medicine methods.

The major concern in design and development will be payed to elimination of known limitations and disadvantages which prevents the therapeutic centers to meet the requirements of the legislations which will consequently enable to apply principals of personalized medicine in administrations of the therapeutic radio-pharmaceuticals.

  • The main goal of the project is development of the new generation mobile robotic imaging camera prototype for thyroid gland and small organs imaging by nuclear medicine methods in diagnostic and therapeutic procedures in human medicine.

MEMBERS OF CONSORTIUM

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    Radalytica a.s.

    Radalytica a.s. is going to integrate the imaging system into the final solution within developing the control software and imaging software.

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    Advacam s.r.o.

    Advacam is developing imaging solutions for industrial and academic needs.

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    Czech Metrology Institut

    Czech Metrology Institut will do Monte Carlo simulations and imaging methodology.

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    First Faculty of Medicine

    First Faculty of Medicine of Charles University, Center of advanced preclinical imaging will do preclinical tests on small animals.

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    Motol University Hospital

    Clinic of nuclear medicine and endocrinology will do clinical tests on human patients.

Strategy of the consortium is development of advanced imaging system dedicated primarily to thyroid gland monitoring

Before the administration of therapeutic radioiodine

  • ✓ Providing detailed information about the size a topography of the gland’s remnants.

  • ✓ Providing data for the optimal radioiodine activity for those thyroid tissue remnants ablation.

During the treatment

  • ✓ Verifying the distribution of therapeutic activity in the target volume.

  • ✓ Providing the information about dynamics of accumulation of radioiodine.

After radioiodine treatment

  • ✓ For the determination of patient’s homecare-release radioiodine activity.

  • By final product our consortium understands the advanced camera integrating two highly innovative elements:

    • ✓ Detector in Compton camera configuration based on hybrid pixel detectors technology of physical pixel size of 55 µm.

    • ✓ Collaborative robotic arm which enables as planar as 3D volume reconstruction of data acquired directly on the patient’s bed without the need of transportation to a dedicated gamma camera inspection room which minimizes the possible contamination and irradiation of the personnel and other staff.

The prototype of the ThyroPIX Camera
Detection of water in honeycomb structure-Use case

ThyroPIX - Innovative robot to help cancer patients

This video presents the prototyp of the newly developed robotic device, which could help to more accurately map the distribution of radioactive iodine in the detection and treatment of thyroid tumors. Thanks to the groundbreaking miniaturized gamma camera, capable of determining the direction of incoming radiation, it precisely locates where and how the radiopharmaceutical acts.

Watch
Compton camera - source schema
Results – Reconstruction methods experiment

ThyroPIX will be equipped also with:

  • ✓ Proprietary hardware (control unit) and software for motion control of the robot.

  • ✓ Acquisition software for data collection in planar and SPECT modes.

  • ✓ Processing software.

  • ✓ Software modules for compatibility and communication with systems - NIS/RIS a PACS.

  • ✓ Suitable hardware (PC) with all the software packages.

  • ✓ Equipment for wireless data handling.

  • ✓ Optional upgrade with other software packages.

Developed camera will be intended as:

  • ✓ Dedicated for diagnostic imaging and imaging of therapeutic activities assuring the measurements in required number and periods.

  • ✓ Offering significantly better resolutio - 2D - <2 mm a SPECT - <0,5 ml.

  • ✓ Substantially shortening acquisition time because of no collimator implementation (especially in SPECT).

  • ✓ Enabling detection of high photon fluxes for verification of spatial distribution of therapeutic radiopharmaceuticals.

  • Thanks to flexibility and automatic robotic arm positioning the patient can sit on the chair or lie down in bed win his hospital room without the need of his transportation preventing radioactive contamination. Furthermore, the constant positioning assures the correct evaluation of repeated measurements and the trend curves delineation.

    The preparation for IIa risk classification healthcare device certification is also part of the project.

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